منابع مشابه
Ribosome Builder: A software project to simulate the ribosome
The Ribosome Builder is a software project that provides tools and techniques to create dynamic models of macromolecular systems from the rapidly growing numbers of atomic structural models. It includes a computer program that allows the user to assemble the multiple molecular components within a 3D space and to define the hypothetical interactions of these components with the initial goal of u...
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Ribosomopathies compose a collection of disorders in which genetic abnormalities cause impaired ribosome biogenesis and function, resulting in specific clinical phenotypes. Congenital mutations in RPS19 and other genes encoding ribosomal proteins cause Diamond-Blackfan anemia, a disorder characterized by hypoplastic, macrocytic anemia. Mutations in other genes required for normal ribosome bioge...
متن کاملThe ribosome filter hypothesis.
A variety of posttranscriptional mechanisms affects the processing, subcellular localization, and translation of messenger RNAs (mRNAs). Translational control appears to occur primarily at the initiation rather than the elongation stage. It has been suggested that translation is mediated largely by means of a cap-binding/scanning mechanism. On the basis of recent findings, we propose here that ...
متن کاملThe Ribosome in Focus
ing research had led to a general understanding of riboThe recent solution of ribosome structure at atomic ressome morphology and function. Electron microscopy of olution by X-ray crystallography represents a quantum negatively stained 50S and 30S subunits from E. coli leap in our understanding of the mechanism of protein showed that the former possesses a chunky, almost synthesis. Notably, the...
متن کاملThe ribosome returned
Since the mid-1990s, insights obtained from electron microscopy and X-ray crystallography have transformed our understanding of how the most important ribozyme in the cell, the ribosome, catalyzes protein synthesis. This review provides a brief account of how this structural revolution came to pass, and the impact it has had on our understanding of how the ribosome decodes messenger RNAs.
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ژورنال
عنوان ژورنال: RNA
سال: 2014
ISSN: 1355-8382
DOI: 10.1261/rna.043653.113